The Next Frontier in Bioengineering

July 15, 2019

A new HIV treatment aimed at women could be on the horizon with Phil Santangelo’s RNA-based solutions

Women continue to be disproportionally affected by HIV around the world, but particularly in sub-Saharan Africa, where three in four new HIV infections are among young girls. For women seeking care in developing countries, preventing and managing HIV is an expensive proposition. Truvada, the pre-exposure HIV treatment drug commonly known as PrEP, costs about $1,500 a month and must be taken daily for continual HIV protection. Likewise, the antiretroviral therapies that attempt to control HIV infection are costly at nearly $20,000 a year. These oral medications as therapy are a non-starter in developing nations like Africa, where nearly 30 million people are infected with HIV.

But Phil Santangelo, biomedical engineering professor at Georgia Tech, has another approach in mind. He’s working on an aerosolized RNA-based HIV preventative that eventually could protect women against the disease. It’s applied vaginally and, currently, the aerosol has been tested in pre-clinical trials. The early results are promising; it’s been shown to create HIV antibodies that ward off the infection. It also has the potential to protect against genital herpes and other pathogens, depending on what protein the RNA encodes for.

“A single administration of this aerosol is showing expression of antibodies against HIV for up to three months in pre-clinical trials,” said Santangelo. “Our hope is that this will be more affordable, granting easier access to women in developing countries, especially. With women’s health at the forefront of many conversations today, this has the potential to revolutionize disease prevention.”

A look inside Phil Santangelo's lab

Eventually, Santangelo says RNA could be used for contraception as well – the RNA would express antibodies that inhibit sperm. Again, if birth control can’t be accessed in developing countries, a self-administered, inexpensive aerosol could change the lives of many women.

So, how does this seemingly magical preventative work? In Santangelo’s lab, he manufactures RNA – the messenger molecule that typically encodes proteins, which help the body create cells and thrive. Because RNA can more easily enter the body’s cells, it is very effective when used for various therapeutics and vaccines. It’s a safer option, and it’s transient – meaning the RNA therapy can be used for a shorter amount of time to treat the disease, but also be administered again if needed. RNA can easily cross into the body via mucosal membranes existing in the cervix, vagina and uterus, which is especially important for the female HIV preventative.  

“With RNA-based solutions, the body can easily produce the antibodies that prevent the disease when administered as an aerosol,” said Santangelo. “It also ensures the treatment is localized, which is critical.”

Women and HIV

  • 18.8 million women and girls are living with HIV

  • AIDS-related illnesses are the leading cause of death among females between the age of 15 and 49

  • 1.8 million children are born with HIV, contracted from their mothers

  • In sub-Saharan Africa, 3 in 4 new HIV infections in teenagers are among girls

  • There are 5,000 new HIV infections per day

Santangelo envisions greater access to this type of treatment as well.

“Women would be able to discreetly purchase an aerosol that protects against various diseases, use it and then throw it away, avoiding social stigma,” said Santangelo. “They would have complete control of their health. We still need to work on applicator design, but the data is really exciting and promising.”

Santangelo also works on RNA therapies that prevent RSV – a respiratory illness that affects babies and immunocompromised people. The treatment is inhaled, so it goes directly to the lungs to administer the antibodies. A patient could be protected for months with one dose of the therapy. Currently in pre-clinical trials, the aerosol is seen to protect against RSV for more than a month.

Another aerosolized treatment, a flu vaccine taken via an inhaler, could also be on the horizon, helping the lungs resist flu infection.

“In addition to RNA expression of antibodies, we have also moved towards the use of RNA editors as antiviral drugs,” said Santangelo. “We are working with the U.S. Department of Defense to aerosolize these with the goal of eventually coming up with a flu treatment. If we can administer it via the lung, protection is going to be far greater than an injection, and the general public will greatly benefit from this.”

While the future of aerosol treatments is still uncertain, Santangelo is excited by the prospect of having treatments ready for human drug trials by 2024.

Santagelo in his lab. 

Recent News

Group of organizers

Siemens and Georgia Tech Launch New Center Focused Optimizing Infrastructure Systems

The $1.8 million investment from Siemens will prepare students to enter the STEM workforce of the future while improving upon the role of digital engineering for buildings. 
Oct 15 2021
liquid flow assay developed in the Sarioglu lab

Building a Better Dipstick Test

The Sarioglu lab is taming the flow on new, improved, user-friendly disposable lab tests.
Oct 15 2021
Arijit Raychowdhury

Raychowdhury Selected as New Chair of Electrical and Computer Engineering

Arijit Raychowdhury, professor in the School of Electrical and Computer Engineering, is the next Steve W. Chaddick School Chair, effective December 1. 
Oct 13 2021
Yellowstone National Park

$12M NSF Grant to Establish Atmospheric Measurement Network

Aerosol counters in national parks and big cities will provide more data and greater understanding about air pollutants.
Oct 7 2021
Researchers standing next to equipment

Georgia Tech to Enhance Nation's Hypersonics Capabilities with Dept. of Defense Grants

Hypersonic systems would allow aircraft to travel at a speed five times the speed of sound, or one mile per second. 
Oct 6 2021